Publication: Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF164
Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF164
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Sacchi, V., Mittermayr, R., Hartinger, J., Martino, M. M., Lorentz, K. M., Wolbank, S., Hofmann, A., Largo, R. A., Marschall, J. S., Groppa, E., Gianni-Barrera, R., Ehrbar, M., Hubbell, J. A., Redl, H., & Banfi, A. (2014). Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF164. Proceedings of the National Academy of Sciences of the United States of America, 111(19), 6952–6957. https://doi.org/10.1073/pnas.1404605111
Abstract
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Abstract
Clinical trials of therapeutic angiogenesis by vascular endothelial growth factor (VEGF) gene delivery failed to show efficacy. Major challenges include the need to precisely control in vivo distribution of growth factor dose and duration of expression. Recombinant VEGF protein delivery could overcome these issues, but rapid in vivo clearance prevents the stabilization of induced angiogenesis. Here, we developed an optimized fibrin platform for controlled delivery of recombinant VEGF, to robustly induce normal, stable, and functional
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Creators (Authors)
- Sacchi, Veronica
- Mittermayr, Rainer
- Hartinger, Joachim
- Martino, Mikaël M
- Lorentz, Kristen M
- Wolbank, Susanne
- Hofmann, Anna
- Marschall, Jeffrey S
- Groppa, Elena
- Gianni-Barrera, Roberto
- Hubbell, Jeffrey A
- Redl, Heinz
- Banfi, Andrea
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Citations
Sacchi, V., Mittermayr, R., Hartinger, J., Martino, M. M., Lorentz, K. M., Wolbank, S., Hofmann, A., Largo, R. A., Marschall, J. S., Groppa, E., Gianni-Barrera, R., Ehrbar, M., Hubbell, J. A., Redl, H., & Banfi, A. (2014). Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF164. Proceedings of the National Academy of Sciences of the United States of America, 111(19), 6952–6957. https://doi.org/10.1073/pnas.1404605111
