Publication: Uptake of ferromagnetic carbon-encapsulated metal nanoparticles in endothelial cells: influence of shear stress and endothelial activation
Uptake of ferromagnetic carbon-encapsulated metal nanoparticles in endothelial cells: influence of shear stress and endothelial activation
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Jacobson, M., Roth Z’graggen, B., Graber, S. M., Schumacher, C. M., Stark, W. J., Dumrese, C., Mateos, J. M., Aemisegger, C., Ziegler, U., Urner, M., Herrmann, I. K., & Beck-Schimmer, B. (2015). Uptake of ferromagnetic carbon-encapsulated metal nanoparticles in endothelial cells: influence of shear stress and endothelial activation. Nanomedicine, 10(24), 3537–3546. https://doi.org/10.2217/nnm.15.172
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AIM Magnetic field guided drug targeting holds promise for more effective cancer treatment. Intravascular application of magnetic nanoparticles, however, bears the risk of potentially important, yet poorly understood side effects, such as off-target accumulation in endothelial cells. MATERIALS & METHODS Here, we investigated the influence of shear stress (0-3.22 dyn/cm(2)), exposure time (5-30 min) and endothelial activation on the uptake of ferromagnetic carbon-encapsulated iron carbide nanomagnets into endothelial cells in an in
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- Jacobson, Melanie
- Roth Z'graggen, Birgit
- Graber, Sereina M
- Schumacher, Christoph M
- Stark, Wendelin J
- Dumrese, Claudia
- Aemisegger, Caroline
- Ziegler, Urs
- Urner, Martin
- Herrmann, Inge K
- Beck-Schimmer, Beatrice
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Jacobson, M., Roth Z’graggen, B., Graber, S. M., Schumacher, C. M., Stark, W. J., Dumrese, C., Mateos, J. M., Aemisegger, C., Ziegler, U., Urner, M., Herrmann, I. K., & Beck-Schimmer, B. (2015). Uptake of ferromagnetic carbon-encapsulated metal nanoparticles in endothelial cells: influence of shear stress and endothelial activation. Nanomedicine, 10(24), 3537–3546. https://doi.org/10.2217/nnm.15.172