Publication: The photoreceptor cilium and its diseases
The photoreceptor cilium and its diseases
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Bachmann-Gagescu, R., & Neuhauss, S. C. F. (2019). The photoreceptor cilium and its diseases. Current Opinion in Genetics & Development, 56, 22–33. https://doi.org/10.1016/j.gde.2019.05.004
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Light sensation occurs in photoreceptor outer segments (OS), which derive from highly specialized primary cilia, based on structural and molecular similarities. Ciliary dysfunction causes ciliopathies, in which retinal degeneration is common. The connecting cilium (CC) is the obligate passage for proteins moving between ciliary and cellular compartment, controlling the correct distribution of proteins on either side of its barrier. While new mechanisms for selective entry of ciliary proteins are being elucidated, active transport out
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Bachmann-Gagescu, R., & Neuhauss, S. C. F. (2019). The photoreceptor cilium and its diseases. Current Opinion in Genetics & Development, 56, 22–33. https://doi.org/10.1016/j.gde.2019.05.004