Publication: Loss of sodium chloride co-transporter impairs the outgrowth of the renal distal convoluted tubule during renal development
Loss of sodium chloride co-transporter impairs the outgrowth of the renal distal convoluted tubule during renal development
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Schnoz, C., Carrel, M., & Loffing, J. (2020). Loss of sodium chloride co-transporter impairs the outgrowth of the renal distal convoluted tubule during renal development. Nephrology, Dialysis, Transplantation, 35(3), 411–432. https://doi.org/10.1093/ndt/gfz172
Abstract
Abstract
Abstract
BACKGROUND: oss-of-function mutations in the sodium chloride (NaCl) co-transporter (NCC) of the renal distal convoluted tubule (DCT) cause Gitelman syndrome with hypokalemic alkalosis, hypomagnesemia and hypocalciuria. Since Gitelman patients are usually diagnosed around adolescence, we tested the idea that a progressive regression of the DCT explains the late clinical onset of the syndrome. METHODS: CC wild-type and knockout (ko) mice were studied at Days 1, 4 and 10 and 6 weeks after birth using blood plasma analysis and morphologic
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- Schnoz, Christina
- Carrel, Monique
- Loffing, Johannes
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Citations
Schnoz, C., Carrel, M., & Loffing, J. (2020). Loss of sodium chloride co-transporter impairs the outgrowth of the renal distal convoluted tubule during renal development. Nephrology, Dialysis, Transplantation, 35(3), 411–432. https://doi.org/10.1093/ndt/gfz172
