Publication: Adjuvant Chemotherapy Increases Programmed Death-Ligand 1 (PD-L1) Expression in Non-small Cell Lung Cancer Recurrence
Adjuvant Chemotherapy Increases Programmed Death-Ligand 1 (PD-L1) Expression in Non-small Cell Lung Cancer Recurrence
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Lacour, M., Hiltbrunner, S., Lee, S.-Y., Soltermann, A., Rushing, E. J., Soldini, D., Weder, W., & Curioni-Fontecedro, A. (2019). Adjuvant Chemotherapy Increases Programmed Death-Ligand 1 (PD-L1) Expression in Non-small Cell Lung Cancer Recurrence. Clinical Lung Cancer, 20, 391–396. https://doi.org/10.1016/j.cllc.2019.05.013
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BACKGROUND Despite recent studies, the effect of chemotherapy on programmed death-ligand 1 (PD-L1) expression remains controversial. In this study, we investigated whether PD-L1 expression is affected by platinum-based chemotherapy. Furthermore, we evaluated correlation of PD-L1 expression with oncogenic driver alterations. MATERIALS AND METHODS We retrospectively evaluated changes in PD-L1 expression by immunohistochemical (IHC) analysis in resected specimens and in biopsies at non-small cell lung cancer recurrence in patients receiv
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Creators (Authors)
- Lacour, Max
- Hiltbrunner, Stefanie
- Lee, Seok-Yun
- Soltermann, Alex
- Rushing, Elisabeth Jane
- Soldini, Davide
- Weder, Walter
- Curioni-Fontecedro, Alessandra
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Citations
Lacour, M., Hiltbrunner, S., Lee, S.-Y., Soltermann, A., Rushing, E. J., Soldini, D., Weder, W., & Curioni-Fontecedro, A. (2019). Adjuvant Chemotherapy Increases Programmed Death-Ligand 1 (PD-L1) Expression in Non-small Cell Lung Cancer Recurrence. Clinical Lung Cancer, 20, 391–396. https://doi.org/10.1016/j.cllc.2019.05.013
