Publication: c-Cbl is a critical modulator of the Ron tyrosine kinase receptor
c-Cbl is a critical modulator of the Ron tyrosine kinase receptor
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Penengo, L., Rubin, C., Yarden, Y., & Gaudino, G. (2003). c-Cbl is a critical modulator of the Ron tyrosine kinase receptor. Oncogene, 22, 3669–3679. https://doi.org/10.1038/sj.onc.1206585
Abstract
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Abstract
Ron, the receptor tyrosine kinase (RTK) for the macrophage stimulating protein (MSP), activates multiple signaling pathways by recruiting several positive regulators to a multifunctional docking site. Here we show that stimulation by MSP also recruits a negative regulator, the c-Cbl ubiquitin ligase, to the multifunctional docking site as well as to a juxtamembrane tyrosine autophosphorylation site. c-Cbl recruitment to these two sites results in polyubiquitylation of Ron molecules, which are subsequently sorted for endocytosis and de
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- Penengo, Lorenza
- Rubin, Chanan
- Yarden, Yosef
- Gaudino, Giovanni
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Penengo, L., Rubin, C., Yarden, Y., & Gaudino, G. (2003). c-Cbl is a critical modulator of the Ron tyrosine kinase receptor. Oncogene, 22, 3669–3679. https://doi.org/10.1038/sj.onc.1206585
