Publication: Mutations of BRCA2 in canine mammary tumors and their targeting potential in clinical therapy
Mutations of BRCA2 in canine mammary tumors and their targeting potential in clinical therapy
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Thumser-Henner, P., Nytko, K. J., & Rohrer Bley, C. (2020). Mutations of BRCA2 in canine mammary tumors and their targeting potential in clinical therapy. BMC Veterinary Research, 16(1), 30. https://doi.org/10.1186/s12917-020-2247-4
Abstract
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Abstract
Dogs develop cancer spontaneously with age, with breed-specific risk underlying differences in genetics. Mammary tumors are reported as the most frequent neoplasia in intact female dogs. Their high prevalence in certain breeds suggests a genetic component, as it is the case in human familial breast cancer, distinctly in BRCA2-associated cancers. However, the molecular genetics of BRCA2 in the pathogenesis of canine cancer are still under investigation.Genetic variations of canine BRCA2 comprised single nucleotide polymorphisms, insert
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- Thumser-Henner, Pauline
- Nytko, Katarzyna J
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Thumser-Henner, P., Nytko, K. J., & Rohrer Bley, C. (2020). Mutations of BRCA2 in canine mammary tumors and their targeting potential in clinical therapy. BMC Veterinary Research, 16(1), 30. https://doi.org/10.1186/s12917-020-2247-4
