Publication: Intravenous administration of cardiac progenitor cell-derived exosomes protects against doxorubicin/trastuzumab-induced cardiac toxicity
Intravenous administration of cardiac progenitor cell-derived exosomes protects against doxorubicin/trastuzumab-induced cardiac toxicity
Date
Date
Date
Citations
Milano, G., Biemmi, V., Lazzarini, E., Balbi, C., Ciullo, A., Bolis, S., Ameri, P., Di Silvestre, D., Mauri, P., Barile, L., & Vassalli, G. (2020). Intravenous administration of cardiac progenitor cell-derived exosomes protects against doxorubicin/trastuzumab-induced cardiac toxicity. Cardiovascular Research, 116(2), 383–392. https://doi.org/10.1093/cvr/cvz108
Abstract
Abstract
Abstract
BACKGROUND Combined administration of anthracyclines (e.g., doxorubicin; Dox) and trastuzumab (Trz), a humanized anti-human epidermal growth factor receptor 2 (HER2; ErbB2), is an effective treatment for HER2-positive breast cancer. However, both agents are associated with cardiac toxicity. Human cardiac-resident mesenchymal progenitor cells (CPCs) secrete extracellular vesicles including nanosized exosomes which protect against myocardial ischemia. Here, we investigated the effects of these exosomes using a novel model of Dox/Trz-med
Additional indexing
Creators (Authors)
- Milano, Giuseppina
- Biemmi, Vanessa
- Lazzarini, Edoardo
- Balbi, Carolina
- Ciullo, Alessandra
- Bolis, Sara
- Ameri, Pietro
- Di Silvestre, Dario
- Mauri, Pierluigi
- Barile, Lucio
- Vassalli, Giuseppe
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Citations
Milano, G., Biemmi, V., Lazzarini, E., Balbi, C., Ciullo, A., Bolis, S., Ameri, P., Di Silvestre, D., Mauri, P., Barile, L., & Vassalli, G. (2020). Intravenous administration of cardiac progenitor cell-derived exosomes protects against doxorubicin/trastuzumab-induced cardiac toxicity. Cardiovascular Research, 116(2), 383–392. https://doi.org/10.1093/cvr/cvz108
