Emerging transporters of clinical importance: an update from the International Transporter Consortium

Hillgren, K M; Keppler, D; Zur, A A; Giacomini, K M; Stieger, B; Cass, C E; Zhang, L

doi:10.1038/clpt.2013.74

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Hillgren, K. M., Keppler, D., Zur, A. A., Giacomini, K. M., Stieger, B., Cass, C. E., & Zhang, L. (2013). Emerging transporters of clinical importance: an update from the International Transporter Consortium. Clinical Pharmacology and Therapeutics, 94(1), 52–63. https://doi.org/10.1038/clpt.2013.74

Abstract

The International Transporter Consortium (ITC) has recently described seven transporters of particular relevance to drug development. Based on the second ITC transporter workshop in 2012, we have identified additional transporters of emerging importance in pharmacokinetics, interference of drugs with transport of endogenous compounds, and drug-drug interactions (DDIs) in humans. The multidrug and toxin extrusion proteins (MATEs, gene symbol SLC47A) mediate excretion of organic cations into bile and urine. MATEs are important in renal