Publication: Quantifying the fitness cost of HIV-1 drug resistance mutations through phylodynamics
Quantifying the fitness cost of HIV-1 drug resistance mutations through phylodynamics
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Kühnert, D., Kouyos, R., Shirreff, G., Pečerska, J., Scherrer, A. U., Böni, J., Yerly, S., Klimkait, T., Aubert, V., Günthard, H. F., Stadler, T., Bonhoeffer, S., & Swiss HIV Cohort Study. (2018). Quantifying the fitness cost of HIV-1 drug resistance mutations through phylodynamics. PLoS Pathogens, 14(2), e1006895. https://doi.org/10.1371/journal.ppat.1006895
Abstract
Abstract
Abstract
Drug resistant HIV is a major threat to the long-term efficacy of antiretroviral treatment. Around 10% of ART-naïve patients in Europe are infected with drug-resistant HIV type 1. Hence it is important to understand the dynamics of transmitted drug resistance evolution. Thanks to routinely performed drug resistance tests, HIV sequence data is increasingly available and can be used to reconstruct the phylogenetic relationship among viral lineages. In this study we employ a phylodynamic approach to quantify the fitness costs of major re
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Creators (Authors)
- Kühnert, Denise
- Kouyos, Roger
- Shirreff, George
- Pečerska, Jūlija
- Scherrer, Alexandra U
- Böni, Jürg
- Yerly, Sabine
- Klimkait, Thomas
- Aubert, Vincent
- Günthard, Huldrych F
- Stadler, Tanja
- Bonhoeffer, Sebastian
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Citations
Kühnert, D., Kouyos, R., Shirreff, G., Pečerska, J., Scherrer, A. U., Böni, J., Yerly, S., Klimkait, T., Aubert, V., Günthard, H. F., Stadler, T., Bonhoeffer, S., & Swiss HIV Cohort Study. (2018). Quantifying the fitness cost of HIV-1 drug resistance mutations through phylodynamics. PLoS Pathogens, 14(2), e1006895. https://doi.org/10.1371/journal.ppat.1006895
