Publication: The effects of farnesoid X receptor activation on arachidonic acid metabolism, NF-kB signaling and hepatic inflammation
The effects of farnesoid X receptor activation on arachidonic acid metabolism, NF-kB signaling and hepatic inflammation
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Gai, Z., Visentin, M., Gui, T., Zhao, L., Thasler, W. E., Hausler, S., Hartling, I., Cremonesi, A., Hiller, C., & Kullak-Ublick, G. A. (2018). The effects of farnesoid X receptor activation on arachidonic acid metabolism, NF-kB signaling and hepatic inflammation. Molecular Pharmacology, 94(2), 802–811. https://doi.org/10.1124/mol.117.111047
Abstract
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Abstract
Inflammation has a recognized role in non-alcoholic fatty liver disease (NAFLD) progression. The present work studied the effect of high fat diet (HFD) on arachidonic acid metabolism in the liver and investigated the role of the farnesoid X receptor (FXR, NR1H4) in eicosanoid biosynthetic pathways and NF-kB signaling, major modulators of the inflammatory cascade. Mice were fed a HFD to induce NAFLD, then, treated with the FXR ligand obeticholic acid (OCA). Histology and gene expression analysis were performed on liver tissue. Eicosano
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Creators (Authors)
- Gai, Zhibo
- Gui, Ting
- Zhao, Lin
- Hausler, Stephanie
- Hartling, Ivan
- Hiller, Christian
- Kullak-Ublick, Gerd A
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Gai, Z., Visentin, M., Gui, T., Zhao, L., Thasler, W. E., Hausler, S., Hartling, I., Cremonesi, A., Hiller, C., & Kullak-Ublick, G. A. (2018). The effects of farnesoid X receptor activation on arachidonic acid metabolism, NF-kB signaling and hepatic inflammation. Molecular Pharmacology, 94(2), 802–811. https://doi.org/10.1124/mol.117.111047
