Publication: Brainstem GLP-1 signalling contributes to cancer anorexia-cachexia syndrome in the rat
Brainstem GLP-1 signalling contributes to cancer anorexia-cachexia syndrome in the rat
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Borner, T., Liberini, C. G., Lutz, T. A., & Riediger, T. (2018). Brainstem GLP-1 signalling contributes to cancer anorexia-cachexia syndrome in the rat. Neuropharmacology, 131, 282–290. https://doi.org/10.1016/j.neuropharm.2017.12.024
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The cancer anorexia-cachexia syndrome (CACS) is a frequent and severe condition in cancer patients. Currently, no pharmacological treatment is approved for the therapy of CACS. Centrally, glucagon-like peptide-1 (GLP-1) is expressed in the nucleus tractus solitarii (NTS) and is implicated in malaise, nausea and food aversion. The NTS is reciprocally connected to brain sites implicated in the control of energy balance including the area postrema (AP), which mediates CACS in certain tumour models. Given the role of GLP-1 as a mediator o
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- Borner, Tito
- Liberini, Claudia G
- Lutz, Thomas A
- Riediger, Thomas
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Citations
Borner, T., Liberini, C. G., Lutz, T. A., & Riediger, T. (2018). Brainstem GLP-1 signalling contributes to cancer anorexia-cachexia syndrome in the rat. Neuropharmacology, 131, 282–290. https://doi.org/10.1016/j.neuropharm.2017.12.024
