Publication: Macrophages preserve endothelial cell specialization in the adrenal gland to modulate aldosterone secretion and blood pressure
Macrophages preserve endothelial cell specialization in the adrenal gland to modulate aldosterone secretion and blood pressure
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Fan, Z., Karakone, M., Nagarajan, S., Nagy, N., Mildenberger, W., Petrova, E., Hinte, L. C., Bijnen, M., Häne, P., Nelius, E., Chen, J., Ferapontova, I., von Meyenn, F., Trepiccione, F., Berber, M., Ribas, D. P., Eichmann, A., Zennaro, M.-C., Takeda, N., … Stockmann, C. (2024). Macrophages preserve endothelial cell specialization in the adrenal gland to modulate aldosterone secretion and blood pressure. Cell Reports, 43(7), 114395. https://doi.org/10.1016/j.celrep.2024.114395
Abstract
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Macrophages play crucial roles in organ-specific functions and homeostasis. In the adrenal gland, macrophages closely associate with sinusoidal capillaries in the aldosterone-producing zona glomerulosa. We demonstrate that macrophages preserve capillary specialization and modulate aldosterone secretion. Using macrophage-specific deletion of VEGF-A, single-cell transcriptomics, and functional phenotyping, we found that the loss of VEGF-A depletes PLVAP$^{+}$ fenestrated endothelial cells in the zona glomerulosa, leading to increased ba
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Creators (Authors)
- Fan, Zheng
- Karakone, Mara
- Nagarajan, Shunmugam
- Nagy, Nadine
- Mildenberger, Wiebke
- Petrova, Ekaterina
- Hinte, Laura Catharina
- Bijnen, Mitchell
- Häne, Philipp
- Nelius, Eric
- Chen, Jing
- Ferapontova, Irina
- von Meyenn, Ferdinand
- Trepiccione, Francesco
- Berber, Mesut
- Ribas, David Penton
- Eichmann, Anne
- Zennaro, Maria-Christina
- Takeda, Norihiko
- Fischer, Jens W
- Spyroglou, Ariadni
- Reincke, Martin
- Loffing, Johannes
- Stockmann, Christian
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Fan, Z., Karakone, M., Nagarajan, S., Nagy, N., Mildenberger, W., Petrova, E., Hinte, L. C., Bijnen, M., Häne, P., Nelius, E., Chen, J., Ferapontova, I., von Meyenn, F., Trepiccione, F., Berber, M., Ribas, D. P., Eichmann, A., Zennaro, M.-C., Takeda, N., … Stockmann, C. (2024). Macrophages preserve endothelial cell specialization in the adrenal gland to modulate aldosterone secretion and blood pressure. Cell Reports, 43(7), 114395. https://doi.org/10.1016/j.celrep.2024.114395
