Publication: Activin signaling disruption in the cochlea does not influence hearing in adult mice
Activin signaling disruption in the cochlea does not influence hearing in adult mice
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Horvath, L., Bodmer, D., Radojevic, V., & Monge Naldi, A. (2014). Activin signaling disruption in the cochlea does not influence hearing in adult mice. Audiology and Neurotology, 20(1), 51–61. https://doi.org/10.1159/000366152
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Activin, a member of the TGF-β superfamily, was found to play an important role in the development, repair and apoptosis of different tissues and organs. Accordingly, activin signaling is involved in the development of the cochlea. Activin binds to its receptor ActRII, then dimerizes with ActRI and induces a signaling pathway resulting in gene expression. A study reported a case of fibrodysplasia ossificans progressiva with an unusual mutation in the ActRI gene leading to sensorineural hearing loss. This draws attention to the role of
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- Horvath, Lukas
- Bodmer, Daniel
- Radojevic, Vesna
- Monge Naldi, Arianne
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Horvath, L., Bodmer, D., Radojevic, V., & Monge Naldi, A. (2014). Activin signaling disruption in the cochlea does not influence hearing in adult mice. Audiology and Neurotology, 20(1), 51–61. https://doi.org/10.1159/000366152
