Publication: Endoglycan plays a role in axon guidance by modulating cell adhesion
Endoglycan plays a role in axon guidance by modulating cell adhesion
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Baeriswyl, T., Dumoulin, A., Schaettin, M., Tsapara, G., Niederkofler, V., Helbling, D., Avilés, E., Frei, J. A., Wilson, N. H., Gesemann, M., Kunz, B., & Stoeckli, E. T. (2021). Endoglycan plays a role in axon guidance by modulating cell adhesion. ELife, 10, e64767. https://doi.org/10.7554/eLife.64767
Abstract
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Abstract
Axon navigation depends on the interactions between guidance molecules along the trajectory and specific receptors on the growth cone. However, our in vitro and in vivo studies on the role of Endoglycan demonstrate that in addition to specific guidance cue - receptor interactions, axon guidance depends on fine-tuning of cell-cell adhesion. Endoglycan, a sialomucin, plays a role in axon guidance in the central nervous system of chicken embryos, but it is neither an axon guidance cue nor a receptor. Rather, Endoglycan acts as a negative
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- Baeriswyl, Thomas
- Schaettin, Martina
- Tsapara, Georgia
- Niederkofler, Vera
- Helbling, Denise
- Avilés, Evelyn
- Frei, Jeannine A
- Wilson, Nicole H
- Gesemann, Matthias
- Kunz, Beat
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Baeriswyl, T., Dumoulin, A., Schaettin, M., Tsapara, G., Niederkofler, V., Helbling, D., Avilés, E., Frei, J. A., Wilson, N. H., Gesemann, M., Kunz, B., & Stoeckli, E. T. (2021). Endoglycan plays a role in axon guidance by modulating cell adhesion. ELife, 10, e64767. https://doi.org/10.7554/eLife.64767
