Publication: Clinical validation of Guardant360 CDx as a blood-based companion diagnostic for sotorasib
Clinical validation of Guardant360 CDx as a blood-based companion diagnostic for sotorasib
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Bauml, J. M., Li, B. T., Velcheti, V., Govindan, R., Curioni-Fontecedro, A., Dooms, C., Takahashi, T., Duda, A. W., Odegaard, J. I., Cruz-Guilloty, F., Jin, L., Zhang, Y., Anderson, A., & Skoulidis, F. (2022). Clinical validation of Guardant360 CDx as a blood-based companion diagnostic for sotorasib. Lung Cancer, 166, 270–278. https://doi.org/10.1016/j.lungcan.2021.10.007
Abstract
Abstract
Abstract
OBJECTIVES
Effective therapy for non-small-cell lung cancer (NSCLC) depends on morphological and genomic classification, with comprehensive screening for guideline-recommended biomarkers critical to guide treatment. Companion diagnostics, which provide robust genotyping results, represent an important component of personalized oncology. We evaluated the clinical validity of Guardant360 CDx as a companion diagnostic for sotorasib for detection of KRAS p.G12C, an important oncogenic NSCLC driver mutation.
MATERIALS AND METHODS
KRAS p
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Creators (Authors)
- Bauml, Joshua M
- Li, Bob T
- Velcheti, Vamsidhar
- Govindan, Ramaswamy
- Curioni-Fontecedro, Alessandra
- Dooms, Christophe
- Takahashi, Toshiaki
- Duda, Andrew W
- Odegaard, Justin I
- Cruz-Guilloty, Fernando
- Jin, Liming
- Zhang, Ying
- Anderson, Abraham
- Skoulidis, Ferdinandos
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Citations
Bauml, J. M., Li, B. T., Velcheti, V., Govindan, R., Curioni-Fontecedro, A., Dooms, C., Takahashi, T., Duda, A. W., Odegaard, J. I., Cruz-Guilloty, F., Jin, L., Zhang, Y., Anderson, A., & Skoulidis, F. (2022). Clinical validation of Guardant360 CDx as a blood-based companion diagnostic for sotorasib. Lung Cancer, 166, 270–278. https://doi.org/10.1016/j.lungcan.2021.10.007
