Publication: Simultaneous hepatic and portal vein ligation induces rapid liver hypertrophy: A study in pigs
Simultaneous hepatic and portal vein ligation induces rapid liver hypertrophy: A study in pigs
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Schadde, E., Guiu, B., Deal, R., Kalil, J., Arslan, B., Tasse, J., Olthof, P. B., Heil, J., Schnitzbauer, A. A., Jakate, S., Breitenstein, S., Schläpfer, M., Schimmer, B. B., & Hertl, M. (2019). Simultaneous hepatic and portal vein ligation induces rapid liver hypertrophy: A study in pigs. Surgery, 165(3), 525–533. https://doi.org/10.1016/j.surg.2018.09.001
Abstract
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Abstract
Background Liver hypertrophy induced by partial portal vein occlusion (PVL) is accelerated by adding simultaneous parenchymal transection (“ALPPS procedure”). This preclinical experimental study in pigs tests the hypothesis that simultaneous ligation of portal and hepatic veins of the liver also accelerates regeneration by abrogation of porto-portal collaterals without need for operative transection. Methods A pig model of portal vein occlusion was compared with the novel model of simultaneous portal and hepatic vein occlusion, where
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Creators (Authors)
- Schadde, Erik
- Guiu, Boris
- Deal, Rebecca
- Kalil, Jennifer
- Arslan, Bulent
- Tasse, Jordan
- Olthof, Pim B
- Heil, Jan
- Schnitzbauer, Andreas A
- Jakate, Shriram
- Breitenstein, Stefan
- Schläpfer, Martin
- Schimmer, Beatrice Beck
- Hertl, Martin
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Schadde, E., Guiu, B., Deal, R., Kalil, J., Arslan, B., Tasse, J., Olthof, P. B., Heil, J., Schnitzbauer, A. A., Jakate, S., Breitenstein, S., Schläpfer, M., Schimmer, B. B., & Hertl, M. (2019). Simultaneous hepatic and portal vein ligation induces rapid liver hypertrophy: A study in pigs. Surgery, 165(3), 525–533. https://doi.org/10.1016/j.surg.2018.09.001
