Publication: Annexin A2-dependent polymerization of actin mediates endosome biogenesis
Annexin A2-dependent polymerization of actin mediates endosome biogenesis
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Morel, E., Parton, R. G., & Gruenberg, J. (2009). Annexin A2-dependent polymerization of actin mediates endosome biogenesis. Developmental Cell, 16(3), 445–457. https://doi.org/10.1016/j.devcel.2009.01.007
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Early endosomes give rise to multivesicular intermediates during transport toward late endosomes. Much progress has been made in understanding the sorting of receptors into these intermediates, but the mechanisms responsible for their biogenesis remain unclear. Here, we report that F-actin is necessary for transport beyond early endosomes and endosome formation. We found that endosomes captured by actin cables were essentially stationary, but early endosomes also exhibited patches of F-actin and facilitated selective F-actin nucleatio
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- Morel, Etienne
- Parton, Robert G
- Gruenberg, Jean
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Citations
Morel, E., Parton, R. G., & Gruenberg, J. (2009). Annexin A2-dependent polymerization of actin mediates endosome biogenesis. Developmental Cell, 16(3), 445–457. https://doi.org/10.1016/j.devcel.2009.01.007
