Publication: Blunted sFasL signalling exacerbates TNF-driven neutrophil necroptosis in critically ill COVID-19 patients
Blunted sFasL signalling exacerbates TNF-driven neutrophil necroptosis in critically ill COVID-19 patients
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Schweizer, T. A., Mairpady Shambat, S., Vulin, C., Hoeller, S., Acevedo, C. T., Huemer, M., Gómez-Mejia, A., Chang, C.-C., Baum, J., Hertegonne, S., Hitz, E., Scheier, T. C., Hofmaenner, D. A., Buehler, P. K., Moch, H., Schuepbach, R. A., Brugger, S. D., & Zinkernagel, A. S. (2021). Blunted sFasL signalling exacerbates TNF-driven neutrophil necroptosis in critically ill COVID-19 patients. Clinical & Translational Immunology, 10, e1357. https://doi.org/10.1002/cti2.1357
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Objectives: Critically ill coronavirus disease 2019 (COVID-19) patients are characterised by a severely dysregulated cytokine profile and elevated neutrophil counts, impacting disease severity. However, it remains unclear how neutrophils contribute to pathophysiology during COVID-19. Here, we assessed the impact of the dysregulated cytokine profile on the regulated cell death (RCD) programme of neutrophils. Methods: Regulated cell death phenotype of neutrophils isolated from critically ill COVID-19 patients or healthy donors and stimu
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Schweizer, T. A., Mairpady Shambat, S., Vulin, C., Hoeller, S., Acevedo, C. T., Huemer, M., Gómez-Mejia, A., Chang, C.-C., Baum, J., Hertegonne, S., Hitz, E., Scheier, T. C., Hofmaenner, D. A., Buehler, P. K., Moch, H., Schuepbach, R. A., Brugger, S. D., & Zinkernagel, A. S. (2021). Blunted sFasL signalling exacerbates TNF-driven neutrophil necroptosis in critically ill COVID-19 patients. Clinical & Translational Immunology, 10, e1357. https://doi.org/10.1002/cti2.1357
