Publication: Flow-dependent regulation of endothelial Tie2 by GATA3 in vivo
Flow-dependent regulation of endothelial Tie2 by GATA3 in vivo
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Idowu, T. O., Etzrodt, V., Pape, T., Heineke, J., Stahl, K., Haller, H., & David, S. (2021). Flow-dependent regulation of endothelial Tie2 by GATA3 in vivo. Intensive Care Medicine Experimental, 9, 38. https://doi.org/10.1186/s40635-021-00402-x
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BACKGROUND Reduced endothelial Tie2 expression occurs in diverse experimental models of critical illness, and experimental Tie2 suppression is sufficient to increase spontaneous vascular permeability. Looking for a common denominator among different critical illnesses that could drive the same Tie2 suppressive (thereby leak inducing) phenotype, we identified "circulatory shock" as a shared feature and postulated a flow-dependency of Tie2 gene expression in a GATA3 dependent manner. Here, we analyzed if this mechanism of flow-regulatio
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Idowu, T. O., Etzrodt, V., Pape, T., Heineke, J., Stahl, K., Haller, H., & David, S. (2021). Flow-dependent regulation of endothelial Tie2 by GATA3 in vivo. Intensive Care Medicine Experimental, 9, 38. https://doi.org/10.1186/s40635-021-00402-x
