Publication: Immune senescence: relative contributions of age and cytomegalovirus infection
Immune senescence: relative contributions of age and cytomegalovirus infection
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Mekker, A., Tchang, V. S., Haeberli, L., Oxenius, A., Trkola, A., & Karrer, U. (2012). Immune senescence: relative contributions of age and cytomegalovirus infection. PLoS Pathogens, 8(8), e1002850. https://doi.org/10.1371/journal.ppat.1002850
Abstract
Abstract
Abstract
Immune senescence, defined as the age-associated dysregulation and dysfunction of the immune system, is characterised by impaired protective immunity and decreased efficacy of vaccines. Recent clinical, epidemiological and immunological studies suggest that Cytomegalovirus (CMV) infection may be associated with accelerated immune senescence, possibly by restricting the naïve T cell repertoire. However, direct evidence whether and how CMV-infection is implicated in immune senescence is still lacking. In this study, we have investigated
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Creators (Authors)
- Mekker, Andrea
- Tchang, Vincent S
- Haeberli, Lea
- Oxenius, Annette
- Trkola, Alexandra
- Karrer, Urs
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Citations
Mekker, A., Tchang, V. S., Haeberli, L., Oxenius, A., Trkola, A., & Karrer, U. (2012). Immune senescence: relative contributions of age and cytomegalovirus infection. PLoS Pathogens, 8(8), e1002850. https://doi.org/10.1371/journal.ppat.1002850
