Publication: Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
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van Gogh, M., Glaus Garzon, J. F., Sahin, D., Knopfova, L., Benes, P., Boyman, O., Jurisica, I., & Borsig, L. (2023). Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model. Cancer Immunology Research, 11(10), 1432–1444. https://doi.org/10.1158/2326-6066.cir-22-0912
Abstract
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Abstract
The transcription factor c-Myb is overexpressed in many different types of solid tumors, including colorectal cancer. However, its exact role in tumorigenesis is unclear. In this study, we show that tumor-intrinsic c-Myb expression in mouse models of colon cancer and melanoma suppresses tumor growth. Although no differences in proliferation, apoptosis, and angiogenesis of tumors were evident in tumors with distinct levels of c-Myb expression, we observed changes in intratumoral immune cell infiltrates. MC38 tumors with upregulated c-M
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- van Gogh, Merel
- Glaus Garzon, Jesus F
- Sahin, Dilara
- Knopfova, Lucia
- Benes, Petr
- Boyman, Onur
- Jurisica, Igor
- Borsig, Lubor
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van Gogh, M., Glaus Garzon, J. F., Sahin, D., Knopfova, L., Benes, P., Boyman, O., Jurisica, I., & Borsig, L. (2023). Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model. Cancer Immunology Research, 11(10), 1432–1444. https://doi.org/10.1158/2326-6066.cir-22-0912
