Publication: Radiosynthesis of [(131)I]IAZGP via nucleophilic substitution and its biological evaluation as a hypoxia marker - is specific activity a factor influencing hypoxia-mapping ability of a hypoxia marker?
Radiosynthesis of [(131)I]IAZGP via nucleophilic substitution and its biological evaluation as a hypoxia marker - is specific activity a factor influencing hypoxia-mapping ability of a hypoxia marker?
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Suehiro, M., Burgman, P., Carlin, S., Burke, S., Yang, G., Ouerfelli, O., Oehler-Janne, C., O’Donoghue, J., Ling, C., & Humm, J. (2009). Radiosynthesis of [(131)I]IAZGP via nucleophilic substitution and its biological evaluation as a hypoxia marker - is specific activity a factor influencing hypoxia-mapping ability of a hypoxia marker? Nuclear Medicine and Biology, 36(5), 477–487. https://doi.org/10.1016/j.nucmedbio.2009.03.002
Abstract
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INTRODUCTION: The hypoxia marker IAZGP, 1-(6-deoxy-6-iodo-beta-d-galactopyranosyl)-2-nitroimidazole, has been labeled with (123)I/(124)I/(125)I/(131)I via iodine-radioiodine exchange, which gives the radiotracer in a specific activity of 10-90 MBq/micromol. We synthesized the same radiotracer possessing several hundred to thousand times higher specific activity (high-SA IAZGP) via nucleophilic substitution and compared its biological behavior with that of conventionally produced IAZGP (low-SA IAZGP) to determine if specific activity i
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- Suehiro, M
- Burgman, P
- Carlin, S
- Burke, S
- Yang, G
- Ouerfelli, O
- Oehler-Janne, C
- O'Donoghue, J
- Ling, C
- Humm, J
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Suehiro, M., Burgman, P., Carlin, S., Burke, S., Yang, G., Ouerfelli, O., Oehler-Janne, C., O’Donoghue, J., Ling, C., & Humm, J. (2009). Radiosynthesis of [(131)I]IAZGP via nucleophilic substitution and its biological evaluation as a hypoxia marker - is specific activity a factor influencing hypoxia-mapping ability of a hypoxia marker? Nuclear Medicine and Biology, 36(5), 477–487. https://doi.org/10.1016/j.nucmedbio.2009.03.002
