Publication: Assessment of serotonin release capacity in the human brain using dexfenfluramine challenge and [(18)F]altanserin positron emission tomography
Assessment of serotonin release capacity in the human brain using dexfenfluramine challenge and [(18)F]altanserin positron emission tomography
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Quednow, B. B., Treyer, V., Hasler, F., Dörig, N., Wyss, M. T., Burger, C., Rentsch, K. M., Westera, G., Schubiger, P. A., Buck, A., & Vollenweider, F. X. (2012). Assessment of serotonin release capacity in the human brain using dexfenfluramine challenge and [(18)F]altanserin positron emission tomography. NeuroImage, 59, 3922–3932. https://doi.org/10.1016/j.neuroimage.2011.09.045
Abstract
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Abstract
Although alterations of serotonin (5-HT) system functioning have been proposed for a variety of psychiatric disorders, a direct method quantitatively assessing 5-HT release capacity in the living human brain is still lacking. Therefore, we evaluated a novel method to assess 5-HT release capacity in vivo using dexfenfluramine challenge and [(18)F]altanserin positron emission tomography (PET). Thirteen healthy male subjects received placebo and single oral doses of 40mg (n=6) or 60mg (n=7) of the potent 5-HT releaser dexfenfluramine sep
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Creators (Authors)
- Hasler, F
- Dörig, N
- Wyss, M T
- Burger, C
- Rentsch, K M
- Westera, G
- Schubiger, P A
- Buck, A
- Vollenweider, F X
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Citations
Quednow, B. B., Treyer, V., Hasler, F., Dörig, N., Wyss, M. T., Burger, C., Rentsch, K. M., Westera, G., Schubiger, P. A., Buck, A., & Vollenweider, F. X. (2012). Assessment of serotonin release capacity in the human brain using dexfenfluramine challenge and [(18)F]altanserin positron emission tomography. NeuroImage, 59, 3922–3932. https://doi.org/10.1016/j.neuroimage.2011.09.045
