Publication: Arginine-vasopressin marker copeptin is a sensitive plasma surrogate of hypoxic exposure
Arginine-vasopressin marker copeptin is a sensitive plasma surrogate of hypoxic exposure
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Ostergaard, L., Rudiger, A., Wellmann, S., Gammella, E., Beck-Schimmer, B., Struck, J., Maggiorini, M., & Gassmann, M. (2014). Arginine-vasopressin marker copeptin is a sensitive plasma surrogate of hypoxic exposure. Hypoxia, 2014, 143–151. https://doi.org/10.2147/HP.S57894
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Background: A reduced oxygen supply puts patients at risk of tissue hypoxia, organ damage, and even death. In response, several changes are activated that allow for at least partial adaptation, thereby increasing the chances of survival. We aimed to investigate whether the arginine vasopressin marker, copeptin, can be used as a marker of the degree of acclimatization/adaptation in rats exposed to hypoxia. Methods: Sprague-Dawley rats were exposed to 10% oxygen for up to 48 hours. Arterial and right ventricular pressures were measured,
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Ostergaard, L., Rudiger, A., Wellmann, S., Gammella, E., Beck-Schimmer, B., Struck, J., Maggiorini, M., & Gassmann, M. (2014). Arginine-vasopressin marker copeptin is a sensitive plasma surrogate of hypoxic exposure. Hypoxia, 2014, 143–151. https://doi.org/10.2147/HP.S57894
