Publication: High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections
High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections
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Olszewski, D., Georgi, F., Murer, L., Andriasyan, V., Kuttler, F., Petkidis, A., Witte, R., Yakimovich, A., Fischer, L., Rozanova, A., Yamauchi, Y., Turcatti, G., & Greber, U. F. (2022). High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections. Scientific Data, 9, 610. https://doi.org/10.1038/s41597-022-01733-4
Abstract
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Abstract
Viruses are genetically and structurally diverse, and outnumber cells by orders of magnitude. They can cause acute and chronic infections, suppress, or exacerbate immunity, or dysregulate survival and growth of cells. To identify chemical agents with pro- or antiviral effects we conducted arrayed high-content image-based multi-cycle infection screens of 1,280 mainly FDA-approved compounds with three human viruses, rhinovirus (RV), influenza A virus (IAV), and herpes simplex virus (HSV) differing in genome organization, composition, pr
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Olszewski, D., Georgi, F., Murer, L., Andriasyan, V., Kuttler, F., Petkidis, A., Witte, R., Yakimovich, A., Fischer, L., Rozanova, A., Yamauchi, Y., Turcatti, G., & Greber, U. F. (2022). High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections. Scientific Data, 9, 610. https://doi.org/10.1038/s41597-022-01733-4
