Publication: Organometallic small molecule kinase inhibitors – direct incorporation of Re and 99mTc into Opaganib®
Organometallic small molecule kinase inhibitors – direct incorporation of Re and 99mTc into Opaganib®
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Lengacher, R., Wang, Y., Braband, H., Blacque, O., Gasser, G., & Alberto, R. (2021). Organometallic small molecule kinase inhibitors – direct incorporation of Re and 99mTc into Opaganib®. Chemical Communications, 57(98), 13349–13352. https://doi.org/10.1039/d1cc03678e
Abstract
Abstract
Abstract
Replacing an adamantyl unit in the protein kinase inhibitor Opaganib® with an integrated [(η$^{5}$-Cp)M(CO)$_{3}$] (M = Re, 99mTc) unit retains the lead's bioactivity and yields a true matched-pair pharmacomimetic.
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- Lengacher, Raphael
- Wang, Youchao
- Gasser, Gilles
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Lengacher, R., Wang, Y., Braband, H., Blacque, O., Gasser, G., & Alberto, R. (2021). Organometallic small molecule kinase inhibitors – direct incorporation of Re and 99mTc into Opaganib®. Chemical Communications, 57(98), 13349–13352. https://doi.org/10.1039/d1cc03678e
