Publication: Immunology of progressive multifocal leukoencephalopathy
Immunology of progressive multifocal leukoencephalopathy
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Jelcic, I., Jelcic, I., Faigle, W., Sospedra, M., & Martin, R. (2015). Immunology of progressive multifocal leukoencephalopathy. Journal of Neurovirology, 21, 614–622. https://doi.org/10.1007/s13365-014-0294-y
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The high prevalence of asymptomatic JC polyomavirus (JCV) infection in the general population indicates coexistence with the human host and efficient immune control in healthy individuals. For unknown reasons, kidney-resident archetypic JCV strains can turn into neurotropic JCV strains which in hereditary or acquired states of immunodeficiency cause opportunistic infection and cytolytic destruction of glial cells or granule cell neurons resulting in progressive multifocal demyelination in the central nervous system (CNS) or cerebellar
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Jelcic, I., Jelcic, I., Faigle, W., Sospedra, M., & Martin, R. (2015). Immunology of progressive multifocal leukoencephalopathy. Journal of Neurovirology, 21, 614–622. https://doi.org/10.1007/s13365-014-0294-y