Impact of UV sterilization and short term storage on the in vitro release kinetics and bioactivity of biomolecules from electrospun scaffolds

Evrova, Olivera; Kellenberger, Damian; Scalera, Chiara; Calcagni, Maurizio; Giovanoli, Pietro; Vogel, Viola; Buschmann, Johanna

doi:10.1038/s41598-019-51513-1

Citations

Citation copied

Evrova, O., Kellenberger, D., Scalera, C., Calcagni, M., Giovanoli, P., Vogel, V., & Buschmann, J. (2019). Impact of UV sterilization and short term storage on the in vitro release kinetics and bioactivity of biomolecules from electrospun scaffolds. Scientific Reports, 9, 15117. https://doi.org/10.1038/s41598-019-51513-1

Abstract

To effectively translate bioactive scaffolds into a preclinical setting, proper sterilization techniques and storage conditions need to be carefully considered, as the chosen sterilization technique and storage condition might affect the structural and mechanical properties of the scaffolds, as well as the bioactivity and release kinetics of the incorporated biomolecules. Since rarely tested or quantified, we show here in a proof-of-concept study how these parameters are affected by UV sterilization and one week storage at different t