Publication: Erythrophagocytes in hemolytic anemia, wound healing, and cancer
Erythrophagocytes in hemolytic anemia, wound healing, and cancer
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Citations
Humar, R., Schaer, D. J., & Vallelian, F. (2022). Erythrophagocytes in hemolytic anemia, wound healing, and cancer. Trends in Molecular Medicine, 28(11), 906–915. https://doi.org/10.1016/j.molmed.2022.08.005
Abstract
Abstract
Abstract
Hemolysis is a ubiquitous pathology defined as premature red blood cell destruction within the circulation or local tissues. One of the most archetypal functions of macrophages is phagocytosis of damaged or extravasated red blood cells, preventing the extracellular release of toxic hemoglobin and heme. Upon erythrophagocytosis, spiking intracellular heme concentrations drive macrophage transformation into erythrophagocytes, leveraging antioxidative and iron recycling capacities to defend against hemolytic stress. This unique phenotype
Additional indexing
Creators (Authors)
- Humar, Rok
- Schaer, Dominik J
- Vallelian, Florence
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Citations
Humar, R., Schaer, D. J., & Vallelian, F. (2022). Erythrophagocytes in hemolytic anemia, wound healing, and cancer. Trends in Molecular Medicine, 28(11), 906–915. https://doi.org/10.1016/j.molmed.2022.08.005
