Publication: Chlamydia suis is associated with intestinal NF-κB activation in experimentally infected gnotobiotic piglets
Chlamydia suis is associated with intestinal NF-κB activation in experimentally infected gnotobiotic piglets
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Aumayer, H., Leonard, C. A., Pesch, T., Prähauser, B., Wunderlin, S., Guscetti, F., & Borel, N. (2020). Chlamydia suis is associated with intestinal NF-κB activation in experimentally infected gnotobiotic piglets. FEMS Pathogens and Disease, 78(6), ftaa040. https://doi.org/10.1093/femspd/ftaa040
Abstract
Abstract
Abstract
Chlamydia suis intestinal infection of single-animal experimental groups of gnotobiotic newborn piglets was previously reported to cause severe, temporary small intestinal epithelium damage. We investigated archived intestinal samples for pro-inflammatory nuclear factor kappa B (NF-κB) activation, Interleukin (IL)-6 and IL-8 production and immune cell influx. Samples were collected 2, 4 and 7 days post-inoculation with C. suis strain S45/6 or mock inoculum (control). Increased nuclear localization of epithelial NF-κB, representative o
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Creators (Authors)
- Aumayer, Helen
- Leonard, Cory Ann
- Pesch, Theresa
- Prähauser, Barbara
- Wunderlin, Sabina
- Guscetti, Franco
- Borel, Nicole
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Citations
Aumayer, H., Leonard, C. A., Pesch, T., Prähauser, B., Wunderlin, S., Guscetti, F., & Borel, N. (2020). Chlamydia suis is associated with intestinal NF-κB activation in experimentally infected gnotobiotic piglets. FEMS Pathogens and Disease, 78(6), ftaa040. https://doi.org/10.1093/femspd/ftaa040
