Publication: Utility of CYP2D6 copy number variants as prognostic biomarker in localized anal squamous cell carcinoma
Utility of CYP2D6 copy number variants as prognostic biomarker in localized anal squamous cell carcinoma
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Trilla‐Fuertes, L., Gámez‐Pozo, A., Nogué, M., Busquier, I., Arias, F., López‐Campos, F., Fernández‐Montes, A., Ruiz, A., Velázquez, C., Martín‐Bravo, C., Pérez‐Ruiz, E., Asensio, E., Hernández‐Yagüe, X., Rodrigues, A., Ghanem, I., López‐Vacas, R., Hafez, A., Arias, P., Dapía, I., … Feliu, J. (2023). Utility of CYP2D6 copy number variants as prognostic biomarker in localized anal squamous cell carcinoma. Cancer, 129(16), 2581–2592. https://doi.org/10.1002/cncr.34797
Abstract
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Background: Anal squamous cell carcinoma (ASCC) is an infrequent tumor whose treatment has not changed since the 1970s. The aim of this study is the identification of biomarkers allowing personalized treatments and improvement of therapeutic outcomes.
Methods: Forty-six paraffin tumor samples from ASCC patients were analyzed by whole-exome sequencing. Copy number variants (CNVs) were identified and their relation to disease-free survival (DFS) was studied and validated in an independent retrospective cohort of 101 ASCC patients from
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- Trilla‐Fuertes, Lucía
- Gámez‐Pozo, Angelo
- Nogué, Miguel
- Busquier, Isabel
- Arias, Fernando
- López‐Campos, Fernando
- Fernández‐Montes, Ana
- Ruiz, Ana
- Velázquez, Concepción
- Martín‐Bravo, Celia
- Pérez‐Ruiz, Elisabeth
- Asensio, Elena
- Hernández‐Yagüe, Xavier
- Rodrigues, Aline
- Ghanem, Ismael
- López‐Vacas, Rocío
- Hafez, Ahmed
- Arias, Pedro
- Dapía, Irene
- Solís, Mario
- Dittmann, Antje
- Ramos, Ricardo
- Llorens, Carlos
- Maurel, Joan
- Campos‐Barros, Ángel
- Fresno Vara, Juan Ángel
- Feliu, Jaime
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Trilla‐Fuertes, L., Gámez‐Pozo, A., Nogué, M., Busquier, I., Arias, F., López‐Campos, F., Fernández‐Montes, A., Ruiz, A., Velázquez, C., Martín‐Bravo, C., Pérez‐Ruiz, E., Asensio, E., Hernández‐Yagüe, X., Rodrigues, A., Ghanem, I., López‐Vacas, R., Hafez, A., Arias, P., Dapía, I., … Feliu, J. (2023). Utility of CYP2D6 copy number variants as prognostic biomarker in localized anal squamous cell carcinoma. Cancer, 129(16), 2581–2592. https://doi.org/10.1002/cncr.34797
