Publication: Maladaptive avoidance learning in the orbitofrontal cortex in adolescents with major depression
Maladaptive avoidance learning in the orbitofrontal cortex in adolescents with major depression
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Willinger, D., Karipidis, I. I., Neuer, S., Emery, S., Rauch, C., Häberling, I., Berger, G. E., Walitza, S., & Brem, S. (2021). Maladaptive avoidance learning in the orbitofrontal cortex in adolescents with major depression (No. 21257570; MedRxiv). https://doi.org/10.1101/2021.05.21.21257570
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BackgroundUnderstanding the mechanisms in the brain’s incentive network that give rise to symptoms of major depressive disorder (MDD) during adolescence provides new perspectives to address MDD in early stages of development. This functional magnetic resonance imaging study determines whether instrumental vigor and brain responses to appetitive and aversive monetary incentives are altered in adolescent MDD and associated with symptom severity.MethodsAdolescents with moderate to severe MDD (n=30, age=16.1 [1.4]), and healthy controls (
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Willinger, D., Karipidis, I. I., Neuer, S., Emery, S., Rauch, C., Häberling, I., Berger, G. E., Walitza, S., & Brem, S. (2021). Maladaptive avoidance learning in the orbitofrontal cortex in adolescents with major depression (No. 21257570; MedRxiv). https://doi.org/10.1101/2021.05.21.21257570
