Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members

Berková, Linda; Fazilaty, Hassan; Yang, Qiutan; Kubovčiak, Jan; Stastna, Monika; Hrckulak, Dusan; Vojtechova, Martina; Dalessi, Tosca; Brügger, Michael David; Hausmann, George; Liberali, Prisca; Korinek, Vladimir; Basler, Konrad; Valenta, Tomas

doi:10.5167/uzh-237591

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Berková, L., Fazilaty, H., Yang, Q., Kubovčiak, J., Stastna, M., Hrckulak, D., Vojtechova, M., Dalessi, T., Brügger, M. D., Hausmann, G., Liberali, P., Korinek, V., Basler, K., & Valenta, T. (2023). Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members. EMBO Reports, 24, e56454. https://doi.org/10.15252/embr.202256454

Abstract

The protective and absorptive functions of the intestinal epithelium rely on differentiated enterocytes in the villi. The differentiation of enterocytes is orchestrated by sub-epithelial mesenchymal cells producing distinct ligands along the villus axis, in particular Bmps and Tgfβ. Here, we show that individual Bmp ligands and Tgfβ drive distinct enterocytic programs specific to villus zonation. Bmp4 is expressed from the centre to the upper part of the villus and activates preferentially genes connected to lipid uptake and metabolis