Publication: Genomic instability of osteosarcoma cell lines in culture: impact on the prediction of metastasis relevant genes
Genomic instability of osteosarcoma cell lines in culture: impact on the prediction of metastasis relevant genes
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Muff, R., Rath, P., Ram Kumar, R. M., Husmann, K., Born, W., Baudis, M., & Fuchs, B. (2015). Genomic instability of osteosarcoma cell lines in culture: impact on the prediction of metastasis relevant genes. PLoS ONE, 10(5), e0125611. https://doi.org/10.1371/journal.pone.0125611
Abstract
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Abstract
BACKGROUND Osteosarcoma is a rare but highly malignant cancer of the bone. As a consequence, the number of established cell lines used for experimental in vitro and in vivo osteosarcoma research is limited and the value of these cell lines relies on their stability during culture. Here we investigated the stability in gene expression by microarray analysis and array genomic hybridization of three low metastatic cell lines and derivatives thereof with increased metastatic potential using cells of different passages. PRINCIPAL FINDING
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- Muff, Roman
- Rath, Prisni
- Ram Kumar, Ram Mohan
- Husmann, Knut
- Born, Walter
- Fuchs, Bruno
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Citations
Muff, R., Rath, P., Ram Kumar, R. M., Husmann, K., Born, W., Baudis, M., & Fuchs, B. (2015). Genomic instability of osteosarcoma cell lines in culture: impact on the prediction of metastasis relevant genes. PLoS ONE, 10(5), e0125611. https://doi.org/10.1371/journal.pone.0125611
