Publication: Antibodies to protein but not glycolipid structures are important for host defense against
Antibodies to protein but not glycolipid structures are important for host defense against
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Meyer Sauteur, P. M., de Bruijn, A. C. J. M., Graça, C., Tio-Gillen, A. P., Estevão, S. C., Hoogenboezem, T., Hendriks, R. W., Berger, C., Jacobs, B. C., van Rossum, A. M. C., Huizinga, R., & Unger, W. W. J. (2018). Antibodies to protein but not glycolipid structures are important for host defense against. Infection and Immunity, 87, e00663-18. https://doi.org/10.1128/IAI.00663-18
Abstract
Abstract
Abstract
Antibody responses to Mycoplasma pneumoniae correlate with pulmonary M. pneumoniae clearance. However, M. pneumoniae-specific IgG antibodies can cross-react with the myelin glycolipid galactocerebroside (GalC) and cause neurological disorders. We assessed whether antiglycolipid antibody formation is part of the physiological immune response to M. pneumoniae We show that antibodies against M. pneumoniae proteins and glycolipids arise in serum of M. pneumoniae-infected children and mice. Although antibodies to M. pneumoniae glycolipids
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- Meyer Sauteur, Patrick M
- de Bruijn, Adrianus C J M
- Graça, Catarina
- Tio-Gillen, Anne P
- Estevão, Silvia C
- Hoogenboezem, Theo
- Hendriks, Rudi W
- Berger, Christoph
- Jacobs, Bart C
- van Rossum, Annemarie M C
- Huizinga, Ruth
- Unger, Wendy W J
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Meyer Sauteur, P. M., de Bruijn, A. C. J. M., Graça, C., Tio-Gillen, A. P., Estevão, S. C., Hoogenboezem, T., Hendriks, R. W., Berger, C., Jacobs, B. C., van Rossum, A. M. C., Huizinga, R., & Unger, W. W. J. (2018). Antibodies to protein but not glycolipid structures are important for host defense against. Infection and Immunity, 87, e00663-18. https://doi.org/10.1128/IAI.00663-18
