Publication: Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity
Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity
Date
Date
Date
Citations
Hotz, A. L., Jamali, A., Rieser, N. N., Niklaus, S., Aydin, E., Myren‐Svelstad, S., Lalla, L., Jurisch‐Yaksi, N., Yaksi, E., & Neuhauss, S. C. F. (2022). Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity. Glia, 70, 196–214. https://doi.org/10.1002/glia.24106
Abstract
Abstract
Abstract
Astroglial excitatory amino acid transporter 2 (EAAT2, GLT-1, and SLC1A2) regulates the duration and extent of neuronal excitation by removing glutamate from the synaptic cleft. Hence, an impairment in EAAT2 function could lead to an imbalanced brain network excitability. Here, we investigated the functional alterations of neuronal and astroglial networks associated with the loss of function in the astroglia predominant eaat2a gene in zebrafish. We observed that eaat2a-/- mutant zebrafish larvae display recurrent spontaneous and light
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Hotz, Adriana L
- Jamali, Ahmed
- Rieser, Nicolas N
- Niklaus, Stephanie
- Aydin, Ecem
- Myren‐Svelstad, Sverre
- Lalla, Laetitia
- Jurisch‐Yaksi, Nathalie
- Yaksi, Emre
Volume
Volume
Volume
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
In collections
Keywords
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Hotz, A. L., Jamali, A., Rieser, N. N., Niklaus, S., Aydin, E., Myren‐Svelstad, S., Lalla, L., Jurisch‐Yaksi, N., Yaksi, E., & Neuhauss, S. C. F. (2022). Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity. Glia, 70, 196–214. https://doi.org/10.1002/glia.24106
