Publication: Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
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Winkler, T. W., Rasheed, H., Teumer, A., Gorski, M., Rowan, B. X., Stanzick, K. J., Thomas, L. F., Tin, A., Hoppmann, A., Chu, A. Y., Tayo, B., Thio, C. H. L., Cusi, D., Chai, J.-F., Sieber, K. B., Horn, K., Li, M., Scholz, M., Cocca, M., … et al. (2022). Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. Communications Biology, 5(1), 580. https://doi.org/10.1038/s42003-022-03448-z
Abstract
Abstract
Abstract
Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (n${DM}$ = 178,691, n${noDM}$ = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 furt
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Creators (Authors)
- Winkler, Thomas W
- Rasheed, Humaira
- Teumer, Alexander
- Gorski, Mathias
- Rowan, Bryce X
- Stanzick, Kira J
- Thomas, Laurent F
- Tin, Adrienne
- Hoppmann, Anselm
- Chu, Audrey Y
- Tayo, Bamidele
- Thio, Chris H L
- Cusi, Daniele
- Chai, Jin-Fang
- Sieber, Karsten B
- Horn, Katrin
- Li, Man
- Scholz, Markus
- Cocca, Massimiliano
- Wuttke, Matthias
- van der Most, Peter J
- Yang, Qiong
- Ghasemi, Sahar
- Nutile, Teresa
- Li, Yong
- Pontali, Giulia
- Günther, Felix
- Dehghan, Abbas
- Correa, Adolfo
- Parsa, Afshin
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Citations
Winkler, T. W., Rasheed, H., Teumer, A., Gorski, M., Rowan, B. X., Stanzick, K. J., Thomas, L. F., Tin, A., Hoppmann, A., Chu, A. Y., Tayo, B., Thio, C. H. L., Cusi, D., Chai, J.-F., Sieber, K. B., Horn, K., Li, M., Scholz, M., Cocca, M., … et al. (2022). Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. Communications Biology, 5(1), 580. https://doi.org/10.1038/s42003-022-03448-z
