Publication: Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor
Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor
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Mori, M., Moraca, F., Deodato, D., Ferraris, D. M., Selchow, P., Sander, P., Rizzi, M., & Botta, M. (2014). Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor. Bioorganic & Medicinal Chemistry Letters, 24(11), 2508–2511. https://doi.org/10.1016/j.bmcl.2014.04.004
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The Mycobacterium tuberculosis extracellular zinc metalloprotease 1 (Zmp1) has been proposed to play a key role in phagosome maturation and to enhance the survival of Mycobacterium tuberculosis in the host. Consequently, small molecule inhibitors of Zmp1 are of pivotal importance as a tool to better understand the pathogenicity of Zmp1 and as lead candidates for pharmacological intervention. Here we combined in silico structure-based inhibitor design with biochemical studies to discover and characterize the first potent competitive Zm
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- Mori, Mattia
- Moraca, Francesca
- Deodato, Davide
- Ferraris, Davide M
- Selchow, Petra
- Sander, Peter
- Rizzi, Menico
- Botta, Maurizio
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Mori, M., Moraca, F., Deodato, D., Ferraris, D. M., Selchow, P., Sander, P., Rizzi, M., & Botta, M. (2014). Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor. Bioorganic & Medicinal Chemistry Letters, 24(11), 2508–2511. https://doi.org/10.1016/j.bmcl.2014.04.004