Publication: Multicenter Validation of Histopathologic Tumor Regression Grade After Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Carcinoma
Multicenter Validation of Histopathologic Tumor Regression Grade After Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Carcinoma
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Voskuilen, C. S., Oo, H. Z., Genitsch, V., Smit, L. A., Vidal, A., Meneses, M., Necchi, A., Colecchia, M., Xylinas, E., Fontugne, J., Sibony, M., Rouprêt, M., Lenfant, L., Côté, J.-F., Buser, L., Saba, K., Furrer, M. A., van der Heijden, M. S., Daugaard, M., … Seiler, R. (2019). Multicenter Validation of Histopathologic Tumor Regression Grade After Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Carcinoma. American Journal of Surgical Pathology, 43(12), 1600–1610. https://doi.org/10.1097/PAS.0000000000001371
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Response classification after neoadjuvant chemotherapy in muscle-invasive bladder carcinoma is based on the TNM stage at radical cystectomy. We recently showed that histopathologic tumor regression grades (TRGs) add prognostic information to TNM. Our aim was to validate the prognostic significance of TRG in muscle-invasive bladder cancer in a multicenter setting. We enrolled 389 patients who underwent cisplatin-based chemotherapy before radical cystectomy in 8 centers between 2010 and 2016. Median follow-up was 2.2 years. TRG was dete
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Voskuilen, C. S., Oo, H. Z., Genitsch, V., Smit, L. A., Vidal, A., Meneses, M., Necchi, A., Colecchia, M., Xylinas, E., Fontugne, J., Sibony, M., Rouprêt, M., Lenfant, L., Côté, J.-F., Buser, L., Saba, K., Furrer, M. A., van der Heijden, M. S., Daugaard, M., … Seiler, R. (2019). Multicenter Validation of Histopathologic Tumor Regression Grade After Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Carcinoma. American Journal of Surgical Pathology, 43(12), 1600–1610. https://doi.org/10.1097/PAS.0000000000001371