Publication: Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19
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Karagiannis, F., Peukert, K., Surace, L., Michla, M., Nikolka, F., Fox, M., Weiss, P., Feuerborn, C., Maier, P., Schulz, S., Al, B., Seeliger, B., Welte, T., David, S., Grondman, I., de Nooijer, A. H., Pickkers, P., Kleiner, J. L., Berger, M. M., … et al. (2022). Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19. Nature, 609(7928), 801–807. https://doi.org/10.1038/s41586-022-05128-8
Abstract
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Anorexia and fasting are host adaptations to acute infection, inducing a metabolic switch towards ketogenesis and the production of ketone bodies, including β-hydroxybutyrate (BHB) 1-6. However, whether ketogenesis metabolically influences the immune response in pulmonary infections remains unclear. Here we report impaired production of BHB in humans with SARS-CoV-2-induced but not influenza-induced acute respiratory distress syndrome (ARDS). CD4+ T cell function is impaired in COVID-19 and BHB promotes both survival and production of
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Karagiannis, F., Peukert, K., Surace, L., Michla, M., Nikolka, F., Fox, M., Weiss, P., Feuerborn, C., Maier, P., Schulz, S., Al, B., Seeliger, B., Welte, T., David, S., Grondman, I., de Nooijer, A. H., Pickkers, P., Kleiner, J. L., Berger, M. M., … et al. (2022). Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19. Nature, 609(7928), 801–807. https://doi.org/10.1038/s41586-022-05128-8
