Publication: Homocysteine metabolism is associated with cerebrospinal fluid levels of soluble amyloid precursor protein and amyloid beta
Homocysteine metabolism is associated with cerebrospinal fluid levels of soluble amyloid precursor protein and amyloid beta
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Oikonomidi, A., Lewczuk, P., Kornhuber, J., Smulders, Y., Linnebank, M., Semmler, A., & Popp, J. (2016). Homocysteine metabolism is associated with cerebrospinal fluid levels of soluble amyloid precursor protein and amyloid beta. Journal of Neurochemistry, 139(2), 324–332. https://doi.org/10.1111/jnc.13766
Abstract
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Disturbed homocysteine metabolism may contribute to amyloidogenesis by modulating the amyloid precursor protein (APP) production and processing. The objective of this study was to investigate the relationships between cerebral amyloid production and both blood and cerebrospinal fluid (CSF) markers of the homocysteine metabolism. We assessed CSF concentrations of soluble APPα, soluble APPβ, and amyloid β1-42 (Aβ1-42), as well as plasma levels of homocysteine (Hcys), total vitamin B12, and folate, and CSF concentrations of homocysteine
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- Oikonomidi, A
- Lewczuk, P
- Kornhuber, J
- Smulders, Y
- Linnebank, M
- Semmler, A
- Popp, J
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Oikonomidi, A., Lewczuk, P., Kornhuber, J., Smulders, Y., Linnebank, M., Semmler, A., & Popp, J. (2016). Homocysteine metabolism is associated with cerebrospinal fluid levels of soluble amyloid precursor protein and amyloid beta. Journal of Neurochemistry, 139(2), 324–332. https://doi.org/10.1111/jnc.13766
