Publication: Placental Passage of Protopine in an Ex Vivo Human Perfusion System
Placental Passage of Protopine in an Ex Vivo Human Perfusion System
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Spiess, D., Abegg, V. F., Chauveau, A., Treyer, A., Reinehr, M., Oufir, M., Duong, E., Potterat, O., Hamburger, M., & Simões-Wüst, A. P. (2022). Placental Passage of Protopine in an Ex Vivo Human Perfusion System. Planta Medica, 87(14), 1192–1205. https://doi.org/10.1055/a-1829-9546
Abstract
Abstract
Abstract
The placental passage of protopine was investigated with a human ex vivo placental perfusion model. The model was first validated with diazepam and citalopram, 2 compounds known to cross the placental barrier, and antipyrine as a positive control. All compounds were quantified by partially validated U(H)PLC-MS/MS bioanalytical methods. Protopine was transferred from the maternal to the fetal circuit, with a steady-state reached after 90 min. The study compound did not affect placental viability or functionality, as glucose consumption
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- Spiess, Deborah
- Abegg, Vanessa Fabienne
- Chauveau, Antoine
- Treyer, Andrea
- Reinehr, Michael
- Oufir, Mouhssin
- Duong, Elisa
- Potterat, Olivier
- Hamburger, Matthias
- Simões-Wüst, Ana Paula
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Spiess, D., Abegg, V. F., Chauveau, A., Treyer, A., Reinehr, M., Oufir, M., Duong, E., Potterat, O., Hamburger, M., & Simões-Wüst, A. P. (2022). Placental Passage of Protopine in an Ex Vivo Human Perfusion System. Planta Medica, 87(14), 1192–1205. https://doi.org/10.1055/a-1829-9546
