Publication: Adeno-associated virus type 2 Rep68 can bind to consensus rep-binding sites on the herpes simplex virus 1 genome
Adeno-associated virus type 2 Rep68 can bind to consensus rep-binding sites on the herpes simplex virus 1 genome
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Seyffert, M., Glauser, D. L., Tobler, K., Georgiev, O., Vogel, R., Vogt, B., Agundez, L., Linden, M., Büning, H., Ackermann, M., & Fraefel, C. (2015). Adeno-associated virus type 2 Rep68 can bind to consensus rep-binding sites on the herpes simplex virus 1 genome. Journal of Virology, 89(21), 11150–11158. https://doi.org/10.1128/JVI.01370-15
Abstract
Abstract
Abstract
Adeno-associated virus type 2 is known to inhibit replication of herpes simplex virus 1 (HSV-1). This activity has been linked to the helicase- and DNA-binding domains of the Rep68/Rep78 proteins. Here, we show that Rep68 can bind to consensus Rep-binding sites on the HSV-1 genome and that the Rep helicase activity can inhibit replication of any DNA if binding is facilitated. Therefore, we hypothesize that inhibition of HSV-1 replication involves direct binding of Rep68/Rep78 to the HSV-1 genome.
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Creators (Authors)
- Glauser, Daniel L
- Tobler, Kurt
- Georgiev, Oleg
- Vogel, Rebecca
- Vogt, Bernd
- Agundez, Leticia
- Linden, Michael
- Büning, Hildegard
- Ackermann, Mathias
- Fraefel, Cornel
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Citations
Seyffert, M., Glauser, D. L., Tobler, K., Georgiev, O., Vogel, R., Vogt, B., Agundez, L., Linden, M., Büning, H., Ackermann, M., & Fraefel, C. (2015). Adeno-associated virus type 2 Rep68 can bind to consensus rep-binding sites on the herpes simplex virus 1 genome. Journal of Virology, 89(21), 11150–11158. https://doi.org/10.1128/JVI.01370-15
