Publication: Thermodynamic and structural factors in the removal of bulky DNA adducts by the nucleotide excision repair machinery
Thermodynamic and structural factors in the removal of bulky DNA adducts by the nucleotide excision repair machinery
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Geacintov, N. E., Broyde, S., Buterin, T., Naegeli, H., Wu, M., Yan, S., & Patel, D. J. (2002). Thermodynamic and structural factors in the removal of bulky DNA adducts by the nucleotide excision repair machinery. Biopolymers, 65(3), 202–210. https://doi.org/10.1002/bip.10239
Abstract
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The function of the human nucleotide excision repair (NER) apparatus is to remove bulky adducts from damaged DNA. In an effort to gain insights into the molecular mechanisms involved in the recognition and excision of bulky lesions, we investigated a series of site specifically modified oligonucleotides containing single, well-defined polycyclic aromatic hydrocarbon (PAH) diol epoxide-adenine adducts. Covalent adducts derived from the bay region PAH, benzo[a]pyrene, are removed by human NER enzymes in vitro. In contrast, the stereoche
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- Geacintov, N E
- Broyde, S
- Buterin, T
- Naegeli, H
- Wu, M
- Yan, S
- Patel, D J
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Geacintov, N. E., Broyde, S., Buterin, T., Naegeli, H., Wu, M., Yan, S., & Patel, D. J. (2002). Thermodynamic and structural factors in the removal of bulky DNA adducts by the nucleotide excision repair machinery. Biopolymers, 65(3), 202–210. https://doi.org/10.1002/bip.10239
