Publication: Structure-Guided Functional Annotation of the Influenza A Virus NS1 Protein Reveals Dynamic Evolution of the p85β-Binding Site during Circulation in Humans
Structure-Guided Functional Annotation of the Influenza A Virus NS1 Protein Reveals Dynamic Evolution of the p85β-Binding Site during Circulation in Humans
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Lopes, A. M., Domingues, P., Zell, R., & Hale, B. G. (2017). Structure-Guided Functional Annotation of the Influenza A Virus NS1 Protein Reveals Dynamic Evolution of the p85β-Binding Site during Circulation in Humans. Journal of Virology, 91, e01081-17. https://doi.org/10.1128/JVI.01081-17
Abstract
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Abstract
Rational characterization of virulence and host-adaptive markers in the multifunctional influenza A virus NS1 protein is hindered by a lack of comprehensive knowledge about NS1-host protein protein interfaces. Here, we surveyed the impact of amino acid variation in NS1 at its structurally defined binding site for host p85β, a regulator of phosphoinositide 3-kinase (PI3K) signaling. Structure-guided alanine scanning of all viral residues at this interface defined 10 positions contributing to the interaction, with residues 89, 95, 98, 1
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- Lopes, A M
- Domingues, P
- Zell, R
- Hale, B G
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Citations
Lopes, A. M., Domingues, P., Zell, R., & Hale, B. G. (2017). Structure-Guided Functional Annotation of the Influenza A Virus NS1 Protein Reveals Dynamic Evolution of the p85β-Binding Site during Circulation in Humans. Journal of Virology, 91, e01081-17. https://doi.org/10.1128/JVI.01081-17
