Publication: Liposomal aggregates sustain the release of rapamycin and protect cartilage from friction
Liposomal aggregates sustain the release of rapamycin and protect cartilage from friction
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Bordon, G., Ramakrishna, S. N., Edalat, S. G., Eugster, R., Arcifa, A., Vermathen, M., Aleandri, S., Bertoncelj, M. F., Furrer, J., Vermathen, P., Isa, L., Crockett, R., Distler, O., & Luciani, P. (2023). Liposomal aggregates sustain the release of rapamycin and protect cartilage from friction. Journal of Colloid and Interface Science, 650(Part B), 1659–1670. https://doi.org/10.1016/j.jcis.2023.07.087
Abstract
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Abstract
Liposomes show promise as biolubricants for damaged cartilage, but their small size results in low joint and cartilage retention. We developed a zinc ion-based liposomal drug delivery system for local osteoarthritis therapy, focusing on sustained release and tribological protection from phospholipid lubrication properties. Our strategy involved inducing aggregation of negatively charged liposomes with zinc ions to extend rapamycin (RAPA) release and improve cartilage lubrication. Liposomal aggregation occurred within 10 min and was ir
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Creators (Authors)
- Bordon, Gregor
- Ramakrishna, Shivaprakash N
- Edalat, Sam G
- Eugster, Remo
- Arcifa, Andrea
- Vermathen, Martina
- Aleandri, Simone
- Bertoncelj, Mojca Frank
- Furrer, Julien
- Vermathen, Peter
- Isa, Lucio
- Crockett, Rowena
- Distler, Oliver
- Luciani, Paola
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Citations
Bordon, G., Ramakrishna, S. N., Edalat, S. G., Eugster, R., Arcifa, A., Vermathen, M., Aleandri, S., Bertoncelj, M. F., Furrer, J., Vermathen, P., Isa, L., Crockett, R., Distler, O., & Luciani, P. (2023). Liposomal aggregates sustain the release of rapamycin and protect cartilage from friction. Journal of Colloid and Interface Science, 650(Part B), 1659–1670. https://doi.org/10.1016/j.jcis.2023.07.087
