Publication: Testing the cancer stem cell hypothesis in melanoma: The clinics will tell
Testing the cancer stem cell hypothesis in melanoma: The clinics will tell
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Shakhova, O., & Sommer, L. (2013). Testing the cancer stem cell hypothesis in melanoma: The clinics will tell. Cancer Letters, 338(1), 74–81. https://doi.org/10.1016/j.canlet.2012.10.009
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Whether tumorigenic cancer stem cells (CSCs) exist in melanoma has been the focus of much controversy in recent years. A number of studies have pointed to the existence of melanoma cell sub-populations that act as CSCs and can be distinguished from other tumor cells based on specific surface marker expression or specific properties such as the capacity for extensive self-renewal. Other studies failed to identify melanoma stem cells and proposed that the potential to initiate tumors is a wide spread feature in melanoma inherent to most
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Shakhova, O., & Sommer, L. (2013). Testing the cancer stem cell hypothesis in melanoma: The clinics will tell. Cancer Letters, 338(1), 74–81. https://doi.org/10.1016/j.canlet.2012.10.009