Publication: Innovations, challenges, and minimal information for standardization of humanized mice
Innovations, challenges, and minimal information for standardization of humanized mice
Date
Date
Date
Citations
Stripecke, R., Münz, C., Schuringa, J. J., Bissig, K., Soper, B., Meeham, T., Yao, L., Di Santo, J. P., Brehm, M., Rodriguez, E., Wege, A. K., Bonnet, D., Guionaud, S., Howard, K. E., Kitchen, S., Klein, F., Saeb‐Parsy, K., Sam, J., Sharma, A. D., … Shultz, L. (2020). Innovations, challenges, and minimal information for standardization of humanized mice. EMBO Molecular Medicine, 12(7), e8662. https://doi.org/10.15252/emmm.201708662
Abstract
Abstract
Abstract
Mice xenotransplanted with human cells and/or expressing human gene products (also known as "humanized mice") recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a relevant in vivo context for understanding of human-specific physiology and pathologies. Humanized mice have advanced toward mainstream preclinical models and are now at the forefront of biomedical research. Here, we considered innovations and challenges regarding the reconstitution of human immunity
Additional indexing
Creators (Authors)
- Stripecke, Renata
- Münz, Christian
- Schuringa, Jan Jacob
- Bissig, Karl‐Dimiter
- Soper, Brian
- Meeham, Terrence
- Yao, Li‐Chin
- Di Santo, James P
- Brehm, Michael
- Rodriguez, Estefania
- Wege, Anja Kathrin
- Bonnet, Dominique
- Guionaud, Silvia
- Howard, Kristina E
- Kitchen, Scott
- Klein, Florian
- Saeb‐Parsy, Kourosh
- Sam, Johannes
- Sharma, Amar Deep
- Trumpp, Andreas
- Trusolino, Livio
- Bult, Carol
- Shultz, Leonard
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Keywords
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Citations
Stripecke, R., Münz, C., Schuringa, J. J., Bissig, K., Soper, B., Meeham, T., Yao, L., Di Santo, J. P., Brehm, M., Rodriguez, E., Wege, A. K., Bonnet, D., Guionaud, S., Howard, K. E., Kitchen, S., Klein, F., Saeb‐Parsy, K., Sam, J., Sharma, A. D., … Shultz, L. (2020). Innovations, challenges, and minimal information for standardization of humanized mice. EMBO Molecular Medicine, 12(7), e8662. https://doi.org/10.15252/emmm.201708662
