Publication: Rapid Downregulation of H3K4me3 Binding to Immunoregulatory Genes in Altered Gravity in Primary Human M1 Macrophages
Rapid Downregulation of H3K4me3 Binding to Immunoregulatory Genes in Altered Gravity in Primary Human M1 Macrophages
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Vahlensieck, C., Thiel, C. S., Christoffel, S., Herbst, S., Polzer, J., Lauber, B. A., Wolter, S., Layer, L. E., Hinkelbein, J., Tauber, S., & Ullrich, O. (2022). Rapid Downregulation of H3K4me3 Binding to Immunoregulatory Genes in Altered Gravity in Primary Human M1 Macrophages. International Journal of Molecular Sciences, 24, 603. https://doi.org/10.3390/ijms24010603
Abstract
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Abstract
The sensitivity of human immune system cells to gravity changes has been investigated in numerous studies. Human macrophages mediate innate and thus rapid immune defense on the one hand and activate T- and B-cell-based adaptive immune response on the other hand. In this process they finally act as immunoeffector cells, and are essential for tissue regeneration and remodeling. Recently, we demonstrated in the human Jurkat T cell line that genes are differentially regulated in cluster structures under altered gravity. In order to study
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Creators (Authors)
- Vahlensieck, Christian
- Thiel, Cora Sandra
- Christoffel, Swantje
- Herbst, Sabrina
- Polzer, Jennifer
- Lauber, Beatrice Astrid
- Wolter, Saskia
- Layer, Liliana Elisabeth
- Hinkelbein, Jochen
- Tauber, Svantje
- Ullrich, Oliver
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Vahlensieck, C., Thiel, C. S., Christoffel, S., Herbst, S., Polzer, J., Lauber, B. A., Wolter, S., Layer, L. E., Hinkelbein, J., Tauber, S., & Ullrich, O. (2022). Rapid Downregulation of H3K4me3 Binding to Immunoregulatory Genes in Altered Gravity in Primary Human M1 Macrophages. International Journal of Molecular Sciences, 24, 603. https://doi.org/10.3390/ijms24010603
